Target 21: corona_TMPRSS2_v1

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Profile Natalia
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Message 1760 - Posted: 17 Nov 2022, 13:21:56 UTC

Dear Participants,

TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal human tracts. It is a cofactor in SARS-CoV-2 entry, and primes viral proteins. Namely, TMPRSS2 cleaves the viral Spro to expose the fusion peptide for cell entry. We are therefore examining TMPRSS2 as a promising strategy to block viral infection in a host-directed therapeutic and/or prophylactic manner. This work is also a a part of larger viral-host protease inhibition study campaign.

With best wishes,
Team SiDock@home
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mikey
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Message 1763 - Posted: 18 Nov 2022, 2:58:16 UTC - in response to Message 1760.  

Dear Participants,

TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal human tracts. It is a cofactor in SARS-CoV-2 entry, and primes viral proteins. Namely, TMPRSS2 cleaves the viral Spro to expose the fusion peptide for cell entry. We are therefore examining TMPRSS2 as a promising strategy to block viral infection in a host-directed therapeutic and/or prophylactic manner. This work is also a a part of larger viral-host protease inhibition study campaign.

With best wishes,
Team SiDock@home


Does that mean more tasks are coming or is this more of a report on work that's been completed and that the results are now being tested?
Either way it sounds like GREAT news!!!
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PeteC

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Message 1768 - Posted: 24 Nov 2022, 14:18:16 UTC - in response to Message 1760.  

Hi Natalia and the SiDock Team. I am not familiar with the medical / chemical wording used ( hereafter called Technical Voodoo) in this message. WOuld it be possible to have these news snippets translated into simple terms ? I know it can sometimes be difficult to find substitute words but "keeping it simple" is always a good philosophy to follow.

Kind regards and keep up the good work,
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Message boards : News : Target 21: corona_TMPRSS2_v1

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