Vote for the next target!

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Profile Natalia
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Message 2176 - Posted: 26 Jan 2024, 12:36:20 UTC

Dear all, we have obtained results for different targets of SARS-CoV-2. The computations continue, and we want to ask your opinion on the next target. You can vote for one of them until February 5th, 2024.

  • SARS-CoV-2 main protease (3CLpro) further studies

    This is a crucial therapeutic target against SARS-CoV-2. 3CLpro (cysteine protease; EC 3.4.22.69) in particular is crucial for the cleavage of coronavirus polyproteins to form mature non-structural proteins that are themselves essential for viral replication mechanisms. We still need much more research on this target towards new more potent inhibitors.

  • Ebolavirus glycoprotein (GP)

    Ebola virus is a dangerous pathogen to humans and this target could be a perfect study case for PPI-type drug design scenario. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion.

  • Swine acute diarrhea syndrome coronavirus (SADS-CoV PLpro)

    This target would enable us to study the design on multiple related viral targets. Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. The pathogen indicates towards host-jump potential.

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Speedy51

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Message 2177 - Posted: 26 Jan 2024, 21:23:18 UTC
Last modified: 26 Jan 2024, 21:24:31 UTC

I appreciated being able to help choose, are all of these targets going to be able processed on GPU when the application is ready?
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Dom

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Message 2178 - Posted: 27 Jan 2024, 2:23:39 UTC

I think it would be most interesting to help those pigs who are suffering from severe diarrhea and find a treatment that works great for them too.
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Laze

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Message 2179 - Posted: 27 Jan 2024, 7:25:05 UTC - in response to Message 2176.  

Thank you so much for your updates. I value to get the information you send in the messages.

Is it possible that all three targets can be achieved, over time?
I would like to vote on all the three targets. Because they are all important, in my opinion.

Thank you!
With best regards
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a8Pxs8

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Message 2180 - Posted: 27 Jan 2024, 8:02:50 UTC

Love that this is being put to a vote! I vote for 3CLPRO then GP.
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Profile Michael H.W. Weber
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Message 2181 - Posted: 27 Jan 2024, 12:25:51 UTC

Really a very nice idea to have the community select the next target.
Fantastic!

Michael.
President of Rechenkraft.net - This world's first and largest distributed computing organization. We make those things possible that supercomputers don't.
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[AF>Le_Pommier] Jerome_C2005

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Message 2182 - Posted: 28 Jan 2024, 12:13:41 UTC

Already 200 votes, I'm impressed :)

Boinc is not dead ! ;)
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JohnB

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Message 2183 - Posted: 28 Jan 2024, 13:55:32 UTC - in response to Message 2176.  

I vote for the first, 3CLPro
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Profile [AF>Amis des Lapins] chapam

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Message 2184 - Posted: 29 Jan 2024, 8:08:59 UTC - in response to Message 2176.  

Ebolavirus glycoprotein (GP)
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Ivan Ťuch

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Message 2185 - Posted: 29 Jan 2024, 13:54:36 UTC - in response to Message 2176.  

Ebolavirový glykoprotein (GP)
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[AF] Kalianthys

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Message 2186 - Posted: 29 Jan 2024, 18:31:22 UTC

Done.
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Denis

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Message 2187 - Posted: 31 Jan 2024, 11:01:27 UTC

SARS-CoV-2 main protease (3CLpro)
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Lilifa

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Message 2188 - Posted: 4 Feb 2024, 14:05:50 UTC - in response to Message 2176.  

Swine acute diarrhea syndrome coronavirus (SADS-CoV PLpro)
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vasill555

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Message 2189 - Posted: 4 Feb 2024, 14:57:16 UTC

i vote for SADS-CoV PLpro too
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Covid killer

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Message 2199 - Posted: 10 Feb 2024, 21:20:23 UTC

Where can I see the results?
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Speedy51

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Message 2200 - Posted: 11 Feb 2024, 2:15:29 UTC - in response to Message 2199.  

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Covid killer

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Message 2201 - Posted: 11 Feb 2024, 18:09:47 UTC - in response to Message 2200.  

Where can I see the results?

Here https://www.sidock.si/sidock/poll_result.php?id=65b3a7251b64817062725491122


Thank you. A shame to see the next batch of units won't focus on Covid-19, although I respect the democratic decision.

Does anyone know of any other projects who still have covid19-work?
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[AF>Le_Pommier] Jerome_C2005

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Message 2202 - Posted: 12 Feb 2024, 8:43:36 UTC

I'm really impressed to see that 354 people did vote, this is great !
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Mario W

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Message 2205 - Posted: 15 Feb 2024, 5:14:17 UTC

I´m overall impressed about causing a Vote and a Poll for the next Target. I have to say, that i´m using Rosetta@Home from Time to Time but there is a Task Issue sometimes...
well Sorry for the Off-Topic :) How ever, thanks for the Poll and i´m looking forward to see that the Application using the GPU to do some Progress as well.
Thanks in advance for this Project. Hightly Apprechiated.
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