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Target # 22: corona_RdRp_v2
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Send message Joined: 11 Oct 20 Posts: 337 Credit: 25,674,648 RAC: 9,225 |
Dear participants, After doing initial studies on an established SARS-CoV-2 target RNA dependent RNA polymerase (RdRp), we are departing from protease studies and focus on RdRp along with additional NSP targets. Namely, RdRp (NSP12), is responsible for the transcription of viral genes and ultimately replication of the viral genome. The studied active site binds RNA and was previously studied in the context of remdesivir, galidesivir, molnupiravir and several other small molecules. Further reading below:
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Send message Joined: 11 Oct 20 Posts: 337 Credit: 25,674,648 RAC: 9,225 |
We estimate, that tasks runtime on CPU like Ryzen 3900X (with enabled SMT) will be around 16 hours. |
Send message Joined: 18 Oct 22 Posts: 9 Credit: 16,444,715 RAC: 256,623 |
Well it widely varies I guess. On my "old but still good" XEON2697v2, some tasks cross 40 hrs .... |
Send message Joined: 15 Jan 22 Posts: 14 Credit: 4,927,244 RAC: 635 |
@Crissy, Thanks for posting. I was about to abort https://www.sidock.si/sidock/result.php?resultid=77569206 - which has been running > 25 hours; with remaining time = 3days and 10 hours. does suspend/resume muck up these tasks? Thanks, Jay |
Send message Joined: 15 Jan 22 Posts: 14 Credit: 4,927,244 RAC: 635 |
@Crissy, Thanks for posting. I was about to abort https://www.sidock.si/sidock/result.php?resultid=77569206 - which has been running > 25 hours; with remaining time = 3days and 10 hours. does suspend/resume muck up these tasks? Thanks, Jay |
Send message Joined: 27 Nov 22 Posts: 20 Credit: 4,418,270 RAC: 20,649 |
I understand the developer is looking into this but these new units are muddying the situation as to whether these are new 'normal' run times or whether they're truly hanging. Not everyone gets around to checking progress often so I'm guessing we're going to see a stream of 'these units have been hanging for days!' posts soon. Looks like it has begun. |
Send message Joined: 11 Oct 20 Posts: 337 Credit: 25,674,648 RAC: 9,225 |
We estimate, that tasks runtime on CPU like Ryzen 3900X (with enabled SMT) will be around 16 hours. Now more statistics available. Some workunits shorter, but most of them runs ~ 16 .. 26 hours on Ryzen 3900X with SMT. Powerful machines got a big task. Really big! |
Send message Joined: 11 Oct 20 Posts: 337 Credit: 25,674,648 RAC: 9,225 |
... Jay, you can check this tasks. |
Send message Joined: 24 Oct 20 Posts: 24 Credit: 1,084,026 RAC: 0 |
I have a small host running this task for more than 3 days and claiming to be at 43% with a 1 day left deadline, in theory more than 4 days of calculation left : is it worth letting it run ? will it get credited (if it ends) ? |
Send message Joined: 11 Oct 20 Posts: 337 Credit: 25,674,648 RAC: 9,225 |
I have a small host running this task for more than 3 days and claiming to be at 43% with a 1 day left deadline, in theory more than 4 days of calculation left : is it worth letting it run ? will it get credited (if it ends) ? This task is hung. It needs restart. *Sprot* tasks is relatively small - for 2 .. 6 hours. |
Send message Joined: 24 Oct 20 Posts: 24 Credit: 1,084,026 RAC: 0 |
Mmm I couldn't find how to "restart" a task, I tried to suspend it and let it run again, but it seemed to continue the same way, so I cancelled it :/ Thanks for the answer anyway. |
Send message Joined: 24 Oct 20 Posts: 24 Credit: 1,084,026 RAC: 0 |
+ I confirm the other tasks completed last max 2h30 on that small host. |
Send message Joined: 16 Aug 21 Posts: 40 Credit: 17,520,350 RAC: 28,866 |
Mmm I couldn't find how to "restart" a task, I tried to suspend it and let it run again, but it seemed to continue the same way, so I cancelled it :/ You need to turn “leave non GPU tasks in memory” off before you suspend the task or it won’t force a checkpoint restart. |
Send message Joined: 24 Oct 20 Posts: 24 Credit: 1,084,026 RAC: 0 |
Thanks for the info. So far I got another one that ended successfully but it took 1 day 14 hours to complete. And I have another one going the same way. |
Send message Joined: 27 Dec 21 Posts: 19 Credit: 16,646,037 RAC: 16,260 |
For RdRp_v2 target it is a perfectly normal. These are long tasks, even on modern computers the computing time for them can reach up to a day of pure CPU time. On older ones, you can expect 2 days or more. While WUs for Sprot_delta target are relatively short tasks (like 10-15 times shorter/less computing time compared to RdRp_v2) |
Send message Joined: 18 Oct 22 Posts: 9 Credit: 16,444,715 RAC: 256,623 |
Hello Jay, Sometimes "buggy" tasks then drop down to a fraction of time reported but then continue from there. I had tasks crossing 100 hrs and after suspend/resume they went down to 30 something and completed within normal times. If I did not stop them, I guess they would have also crossed the deadline without finishing but wasting CPU/energy. This is why I currently quit this project. Waiting for an improvement to return here :-) Cheers Chris |
Send message Joined: 27 Nov 22 Posts: 20 Credit: 4,418,270 RAC: 20,649 |
This is why I currently quit this project. Waiting for an improvement to return here :-) The improvement happened days ago with the release of version 2.02 units. I've completed over 150 without one issue. |
Send message Joined: 18 Oct 22 Posts: 9 Credit: 16,444,715 RAC: 256,623 |
Thanks for the hint, good thing. I will run dry my Worldcommunitygrid queues and give it another try :-) |
Send message Joined: 10 Feb 22 Posts: 31 Credit: 475,987,794 RAC: 109,582 |
Target 22: corona_RdRp_v2 (%) 33.33% complete congrats! Done by Christmas? |
Send message Joined: 11 Oct 20 Posts: 337 Credit: 25,674,648 RAC: 9,225 |
Target 22: corona_RdRp_v2 (%) 33.33% complete congrats! Done by Christmas? 1/3 in half year. Maybe by next autumn. |
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