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Target 11 - Sprot_delta_v1
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Send message Joined: 9 Oct 20 Posts: 185 Credit: 2,782,517 RAC: 50 |
Dear Participants, We continue diligently with the calculations. Now we are breaking through a series of protease studies to explore a new target, the RBD (receptor-binding domain) Sprot domain surface interacting with ACE2. This is the much-discussed spike protein that also contributed to the naming of coronavirus. We focus here on Sprot from the delta variant (B.1.617.2), specifically a Cryo-EM structure of Sprot with an RBD in up conformation. In comparative variant studies, we will try to determine if there is a specific discrimination upon binding of small ligands. This may help us better understand this PPI surface in further studies and even develop a small molecule probes to study these interactions. Thank You all and we look forward to future studies together! With best wishes, Team SiDock@home |
Send message Joined: 11 Oct 20 Posts: 337 Credit: 25,675,196 RAC: 9,235 |
Hi folks! Also we added some bunches workunits with names like '%Pro_v1_run_3%' - for computations related to part of whole space of projects ligands. Main part of Sprot_delta_v1 workunits will follow by this set. |
Send message Joined: 16 Jan 22 Posts: 20 Credit: 1,085,924 RAC: 0 |
Hi folks! Also we added some bunches workunits with names like '%Pro_v1_run_3%' - for computations related to part of whole space of projects ligands. Main part of Sprot_delta_v1 workunits will follow by this set.Sorry, should that say "will be followed by" or "will follow"? As in which comes first? |
Send message Joined: 11 Oct 20 Posts: 337 Credit: 25,675,196 RAC: 9,235 |
Hi Peter! Tasks "*Eprot_v1_run_3*" are being sent out now and "*Sprot*" - next set. :) |
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