Target 11 - Sprot_delta_v1

Message boards : News : Target 11 - Sprot_delta_v1
Message board moderation

To post messages, you must log in.

AuthorMessage
Profile Natalia
Volunteer moderator
Project administrator
Project developer
Project scientist

Send message
Joined: 9 Oct 20
Posts: 166
Credit: 1,201,531
RAC: 3,801
Message 1485 - Posted: 10 Feb 2022, 13:45:49 UTC
Last modified: 10 Feb 2022, 13:50:35 UTC

Dear Participants,

We continue diligently with the calculations. Now we are breaking through a series of protease studies to explore a new target, the RBD (receptor-binding domain) Sprot domain surface interacting with ACE2. This is the much-discussed spike protein that also contributed to the naming of coronavirus. We focus here on Sprot from the delta variant (B.1.617.2), specifically a Cryo-EM structure of Sprot with an RBD in up conformation. In comparative variant studies, we will try to determine if there is a specific discrimination upon binding of small ligands. This may help us better understand this PPI surface in further studies and even develop a small molecule probes to study these interactions.
Thank You all and we look forward to future studies together!

With best wishes,
Team SiDock@home
ID: 1485 · Rating: 0 · rate: Rate + / Rate - Report as offensive     Reply Quote
hoarfrost
Volunteer moderator
Project administrator
Project developer

Send message
Joined: 11 Oct 20
Posts: 201
Credit: 15,126,952
RAC: 17,446
Message 1488 - Posted: 13 Feb 2022, 14:56:55 UTC

Hi folks! Also we added some bunches workunits with names like '%Pro_v1_run_3%' - for computations related to part of whole space of projects ligands. Main part of Sprot_delta_v1 workunits will follow by this set.
ID: 1488 · Rating: 0 · rate: Rate + / Rate - Report as offensive     Reply Quote
Peter Hucker of the Scottish B...

Send message
Joined: 16 Jan 22
Posts: 11
Credit: 261,903
RAC: 8,856
Message 1489 - Posted: 14 Feb 2022, 20:51:15 UTC - in response to Message 1488.  

Hi folks! Also we added some bunches workunits with names like '%Pro_v1_run_3%' - for computations related to part of whole space of projects ligands. Main part of Sprot_delta_v1 workunits will follow by this set.
Sorry, should that say "will be followed by" or "will follow"? As in which comes first?
ID: 1489 · Rating: 0 · rate: Rate + / Rate - Report as offensive     Reply Quote
hoarfrost
Volunteer moderator
Project administrator
Project developer

Send message
Joined: 11 Oct 20
Posts: 201
Credit: 15,126,952
RAC: 17,446
Message 1490 - Posted: 14 Feb 2022, 22:42:32 UTC - in response to Message 1489.  

Hi Peter! Tasks "*Eprot_v1_run_3*" are being sent out now and "*Sprot*" - next set. :)
ID: 1490 · Rating: 0 · rate: Rate + / Rate - Report as offensive     Reply Quote

Message boards : News : Target 11 - Sprot_delta_v1

©2022 SiDock@home Team