1) Message boards : Cafe : BOINC Competition for High School Students - Computation Moonshot (Message 2204) Posted 13 Feb 2024 by Natalia Post: Great news, let this competition attract new crunchers and raise public interest to scientific computing.

2) Message boards : News : Vote for the next target! (Message 2176) Posted 26 Jan 2024 by Natalia Post: Dear all, we have obtained results for different targets of SARS-CoV-2. The computations continue, and we want to ask your opinion on the next target. You can vote for one of them until February 5th, 2024. SARS-CoV-2 main protease (3CLpro) further studies This is a crucial therapeutic target against SARS-CoV-2. 3CLpro (cysteine protease; EC 3.4.22.69) in particular is crucial for the cleavage of coronavirus polyproteins to form mature non-structural proteins that are themselves essential for viral replication mechanisms. We still need much more research on this target towards new more potent inhibitors. Ebolavirus glycoprotein (GP) Ebola virus is a dangerous pathogen to humans and this target could be a perfect study case for PPI-type drug design scenario. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion. Swine acute diarrhea syndrome coronavirus (SADS-CoV PLpro) This target would enable us to study the design on multiple related viral targets. Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. The pathogen indicates towards host-jump potential.

3) Message boards : News : Project status: December 2023 (Message 2154) Posted 26 Dec 2023 by Natalia Post: Dear SiDock@home participants, We've successfully achieved 21 milestones in our ongoing drug discovery initiative, and this strong, open, and community-supported drug discovery project is going on. Our research has been routine lately: virtual screening on the same library for a pleiade of corona-related targets. These efforts are however crucial to our research progression. Currently, we're in the process of drafting publications for two of our completed objectives (3CLpro and PLpro) and are setting the stage for upcoming drug targets (here we are also planning a pool where You the participants, will help us decide on the upcoming target work). Last but not least, we thank everyone who has donated cryptocurrency or money. The donations sum up to 639 Euro and 12,140 Gridcoin now. We plan to use them for purchase of compounds and in-vitro screening. As always, we are grateful to all of you for your computational contributions and discussions! We look forward to the future work on SiDock@home. Merry Christmas to all and all the best to All! With best wishes, Natalia, Marko, Črtomir and hoarfrost

4) Message boards : News : BOINC merchandise by the Science Commons Initiative (Message 2005) Posted 23 Feb 2023 by Natalia Post: Dear participants, There is a wonderful new beginning started by the Science Commons Initiative. They launched a web store selling BOINC-related merchandise. SiDock@home is already on board :) We support this idea and hope it will help more people to know about BOINC and get interested in BOINC projects! It will also contribute to the development of BOINC as 50% of the profits will go to the BOINC Development Fund (100% in special cases). Another 50% of the profit will go to the project as a donation. With best wishes, team of SiDock@home

5) Message boards : News : BOINC Census 2022, be counted! (Message 1985) Posted 10 Feb 2023 by Natalia Post: An update from the Science Commons Initiative: BOINC Census Released!

6) Message boards : Science : Other uses of docking than viruses? (Message 1943) Posted 24 Jan 2023 by Natalia Post: Hello! GPU version of CmDock is under development. The latest CPU version is CmDock v0.2.0, December 2022.

7) Message boards : News : Merry Christmas! (Message 1776) Posted 24 Dec 2022 by Natalia Post: Dear participants, We wish you a merry Christmas and a happy New Year! With your help, we have performed a lot of computer modeling. We are going to continue, and believe the results will lead to advances in drug development! For now, we have a fresh new release of CmDock and will employ it starting from the next target. Here is an illustration of the modeling performed in the project, visualized with PyMOL. You can see a large molecule (this is the target, TMPRSS2 protein) with a molecule many times smaller. The small molecules are ligands, each of them can interact with the target in its own way, with its own binding energy. The more precisely the ligand binds to the target, the higher the chance that it will be able to change the functioning of the large molecule. For example, the TMPRSS2 enzyme shown in the image is necessary for a chemical reaction allowing the coronavirus to enter the body cells and, accordingly, a substance that can suppress the normal operation of this enzyme can make it difficult or block the spread of the coronavirus in it. During the modeling performed on your computers, various ligands from the library are tested, and the best ones are selected to process on next stages of drug development. All the best, Natalia, Marko, hoarfrost, Črtomir

8) Message boards : News : BOINC Census 2022, be counted! (Message 1761) Posted 17 Nov 2022 by Natalia Post: The BOINC Census is a yearly effort aimed at finding out who uses BOINC, what they like about it, and what changes they want to see in the future. Filling out the census is a great way to support this project, the wider BOINC community, and have your input heard for future bug bounties. The census is sponsored by the Science Commons Initiative, and the results will be published in an aggregate, anonymized fashion at the completion of the census. Please take 5 minutes to fill out the census at https://app.fillout.com/flow/esDGuRswWfus

9) Message boards : News : Target 21: corona_TMPRSS2_v1 (Message 1760) Posted 17 Nov 2022 by Natalia Post: Dear Participants, TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal human tracts. It is a cofactor in SARS-CoV-2 entry, and primes viral proteins. Namely, TMPRSS2 cleaves the viral Spro to expose the fusion peptide for cell entry. We are therefore examining TMPRSS2 as a promising strategy to block viral infection in a host-directed therapeutic and/or prophylactic manner. This work is also a a part of larger viral-host protease inhibition study campaign. With best wishes, Team SiDock@home

10) Questions and Answers : Windows : Will not queue more than about 4 work units per core despite set for 10 days of work (Message 1716) Posted 24 Aug 2022 by Natalia Post: At the beginning, we followed the list of targets (groups of work units) that was published in the presentation. Today, new targets are selected following the intermediate computational results and new scientific data. For instance, the target PLpro was investigated 4 times instead of 2 planned initially. This is why it is difficult to publish a planned list in advance.

11) Questions and Answers : Web site : Email notification broken (Message 1696) Posted 12 Aug 2022 by Natalia Post: Email notifications should be fixed now, please check.

12) Questions and Answers : Web site : Update Cross-Project ID (Message 1652) Posted 21 Jun 2022 by Natalia Post: Hello, as I gather, only you can fix it at your side. Following this post, you can either (1) ensure your email addresses match across all the projects you signed up to, connect all your projects to one host and wait 'up to 14 days' for the CPIDs to settle. Or (2) follow the steps listed in the post to fix it immediately. Please tell us if you managed to fix it.

13) Message boards : News : Project status: May 2022 (Message 1645) Posted 9 Jun 2022 by Natalia Post: All current targets are SARS-CoV-2. When we switch to Ebola or other virus, we will say so in the news.

14) Message boards : News : Project status: May 2022 (Message 1637) Posted 31 May 2022 by Natalia Post: Dear all, with your help, we have processed 15 targets already! It is a huge computational work, the results of which are being processed by our team and colleagues. We are working on two papers which will be available to the public as early as possible. We also continue computations for next targets. During March, April and May, project's performance was fluctuating around 250 Teraflops. We took this advantage to prioritize SARS-CoV-2 targets on top of the other research. At the end of spring 2022, we are 6426 active participants with 4493 computers. With best wishes, Natalia and the team of SiDock@home

15) Message boards : Number crunching : corona_PLpro_v4 errors (Message 1625) Posted 18 Apr 2022 by Natalia Post: Yes, we will move to quorum of one to avoid duplicated computations. But before that, we need to implement a robust scheme of results validation.

16) Message boards : News : Project status: March 2022 (Message 1607) Posted 26 Mar 2022 by Natalia Post: I must clarify for everyone that the project is a collaboration between Slovenian and Russian scientists. The main server is in Russia, and the Russian part of the team is responsible for the BOINC side. We respect the right of anyone to stop participating by any reason.

17) Message boards : News : Project status: March 2022 (Message 1605) Posted 26 Mar 2022 by Natalia Post: Everyone: please restrain from political discussions in this forum. You can exchange opinions on other platforms. Any personal opinion is not the official position of our project.

18) Questions and Answers : Web site : High activity (Message 1582) Posted 17 Mar 2022 by Natalia Post: Yes, the project experiences a high load. We have upgraded the hard drive just before the pause in World Community Grid, now we are adjusting the filtering of results to obtain less data from the clients.

19) Message boards : News : Technical maintenance on March 14th, 9:00-10:00 UTC (Message 1569) Posted 13 Mar 2022 by Natalia Post: Dear participants, we plan an hour-long break tomorrow, 9:00-10:00 UTC, for technical works. All the best, Team SiDock@home

20) Questions and Answers : Macintosh : Please provide an app for Mac M1 (Apple Silicon / ARM64) (Message 1566) Posted 10 Mar 2022 by Natalia Post: Mac version is still under development, the team is loaded with other work, but we remember about Mac.

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