Chemical subspaces are defined by the elements included and the size of the largest molecules. ... A complete chemical subspace is defined as a set of molecules, where breaking any bond in any molecule creates fragments that are also part of the subspace

Conclusion

We report a rapidly growing lineage in the UK associated with an unexpectedly large number of genetic changes including in the receptor-binding domain and associated with the furin cleavage site. Given (i) the experimentally-predicted and plausible phenotypic consequences of some of these mutations, (ii) their unknown effects when present in combination, and (iii) the high growth rate of B.1.1.7 in the UK, this novel lineage requires urgent laboratory characterisation and enhanced genomic surveillance worldwide.