News

4000 users with credit
Dear SiDockers,

new breakthrough of the project, we will wellcome 4000th user with the credit, very soon.

;-) Crtomir
21 Sep 2021, 15:17:51 UTC · Discuss


SiDock@home September Sailing
Dear participants!

Just now, your computers are hitting three protein targets at once. Due to the low runtimes and (mainly) the friendly contributions of participants and their teams, the data is being processed fast, and we express our gratitude to all of you.
We announce a new competition between teams, SiDock@home September Sailing. Top winners will get the badges:
1st place:


2nd place:


3rd place:


Heme B, the well-known ligand in the complex of Hemoglobin, helps to carry oxygen in our bloodstream. As we know today, it has emerged from just two mutations that occurred in genome of one of predecessors of modern vertebrates more than 400 million years ago [1,2].

[1] https://phys.org/news/2020-05-reveal-complex-hemoglobin-resurrecting-ancient.html
[2] Pillai, A.S., Chandler, S.A., Liu, Y. et al. Origin of complexity in haemoglobin evolution. Nature 581, 480–485 (2020).
12 Sep 2021, 8:19:15 UTC · Discuss


Targets six, seven, eight
Dear participants,

we have prepared three new targets for you! They all base on 3CLpro protein, a prime target for antiviral drug discovery because of its central involvement in virus replication. Another reason to put them high on the list is that we have a good possibility to test interesting results in a lab. The targets 6, 7 and 8 are X-ray identified allosteric sites on 3Clpro. We will make a limited number of workunits to ensure everything works fine, and then launch full-scale screening on the new targets. We will temporarily pause processing of Target 5 in favour of the new ones.

With best wishes,
Team SiDock@home
28 Aug 2021, 16:18:49 UTC · Discuss


Project status: July 2021
Dear all,

Our research is going on! Collaborators just started biological evaluation of 30 chemical compounds selected in SiDock@home for targets 3CLpro and PLpro. Biological evaluation in vitro works with the most prospective results that your computers have selected in silico. The process is iterative and will involve hundreds of experiments.

With your help, we have already processed 4 targets and 43% of the fifth one. Further workunits will be created basing on the biological evaluation and the latest scientific knowledge about the targets.

Many thanks and best wishes,
Team of SiDock@home
9 Jul 2021, 18:21:50 UTC · Discuss


Donations to SiDock@home
Drug development is a time-consuming and costly process. With help of your computers, our team is able to speed up discovery of prospective candidates for in vitro tests. At the same time, the volume of biological evaluation is limited by funding. We are in constant search for additional sources, and, since SiDock@home allows the participants to earn Gridcoins, we find it a good idea to accept voluntary donations. If you feel like donating to the project, please use one of the listed options.
9 Jul 2021, 18:18:53 UTC · Discuss


... more

News is available as an RSS feed   RSS

What is SiDock@home?

Sidock@home is an international volunteer computing project aimed at drug discovery. The first mission of the project is discovery of possible drugs against the SARS-CoV-2 virus. It started as an extension of the project  COVID.SI to engage the BOINC community into the drug discovery.

You can help with your computer. With the help of BOINC, you will download a subset of compounds on your computer, examine the compounds in the context of the studied target and send the results to a server where they are collected for later analysis.

For account creation please use a Crunch_4Science invitation code. It is not needed when registering by BOINC Manager.

Join SiDock@home

Already joined? Log in.

User of the Day

User profile Profile MarkRBright
Just another ageing Boincer

Donations to SiDock@home

We are going to use donation money for biological evaluation of results.

This project is accepting donations in cryptocurrency:
  • Gridcoin wallet (GRC): SLymYcWWoJrC3vZ1fF4ZVebfbzfs9Kziy9
  • Bitcoin wallet (BTC): 3GaQD2EBsEAgvdPdpkMGJP3JT5zM3uKNn3
  • Ethereum wallet (ETH): 0xd726c8a048c0532e4793D88895d3cE1A637517c8
This project is also accepting donations via PayPal. To donate, fill in the amount you want to donate using the field below. PayPal is accepting multiple currencies. You can use included currency converter to see the donation amount equivalent in different currencies (please note that the rates are only estimates and the actual amount may differ).
Amount you would like to donate
Estimated value in
Anonymous donation
To assign the donation with your user ID, please log in.

 


©2021 SiDock@home Team