News

A poll about distributed computing projects
Dear all,

there is a poll created by students who investigate volunteer computing. The questions aim to explore the motivation of participants. If you wish and have a minute, please express your opinion at https://forms.gle/tcLYdtoeVfMMREPE7. The results will be analyzed and presented to the public. Thank you!

With best wishes,
Team of SiDock@home
24 Nov 2021, 11:51:31 UTC · Discuss


Release CmDock v 0.1.4
Dear community. New release of CmDock was prepared. The v0.1.4 of CmDock incorporates fixed checkpointing and progress bar patch along with support for compressed input and output via cmzip. New CmDock release also includes an Updated SDF-Tools submodule that should help the userbase manipulate input/output files with support for large molecular libraries.

Along with the new release, BOINC client is up to date also. The team is working hard and we are committed to support CmDock in the future. Thank You!

Marko & Natalia
21 Nov 2021, 17:10:00 UTC · Discuss


Ninth and tenth targets
Dear participants,

We have a new target which resides at a novel allosteric site on SARS-CoV-2 main protease. The site was identified by MixMD method [1] with collaboration at College of Pharmacy, University of Michigan. Target preparation was helped by Jelena Tošović (Slovenia).

The two upcoming targets and results will complement the allosteric sites identified with X-ray screening by Sebastian Günther et al. [2]. The targets have good chances for wet-lab testing as soon as possible and further experimental support.

(We will again temporarily pause processing of Target 5)

With best wishes,
Team SiDock@home

[1] Phani Ghanakota and Heather A. Carlson. Moving Beyond Active-Site Detection: MixMD Applied to Allosteric Systems. The Journal of Physical Chemistry B 2016 120 (33), 8685-8695. DOI: 10.1021/acs.jpcb.6b03515
[2] Sebastian Günther et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science 2021 372 (6542), 642-646. DOI: 10.1126/science.abf7945
13 Nov 2021, 9:39:16 UTC · Discuss


November competition
Dear all,

we are glad to announce a November competition! The symbol of the competition is tryptophan. Just like any amino acid, tryptophan serves as a building block in protein biosynthesis. It is also a source to synthesize serotonin, melatonin, and vitamin B3. And just like many vital processes in our bodies, tryptophan biochemistry is affected by SARS-CoV-2 infection ([1-3] etc.).

1st place:
2nd place:
3rd place:

[1] Thomas T, Stefanoni D, Reisz JA, et al. COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status. JCI Insight. 2020;5(14):e140327. Published 2020 Jul 23. doi:10.1172/jci.insight.140327
[2] Eroğlu İ, Eroğlu BÇ, Güven GS. Altered tryptophan absorption and metabolism could underlie long-term symptoms in survivors of coronavirus disease 2019 (COVID-19). Nutrition. 2021;90:111308. doi:10.1016/j.nut.2021.111308
[3] Vyavahare S, Kumar S, Cantu N, et al. Tryptophan-kynurenine pathway in COVID-19-dependent musculoskeletal pathology: a minireview. Mediators of Inflammation. 2021; Article ID 2911578, 6 pages, 2021. doi:10.1155/2021/2911578
28 Oct 2021, 19:08:55 UTC · Discuss


BOINC client 7.16.20 solves the certificate problem for Windows
Dear all,

If you are running BOINC on a Windows computer, please update to a new version (7.16.20) of the BOINC client. The previous version stopped working recently because of an expired SSL file that prevented it from communicating with several BOINC projects, with the BOINC server, and with Science United. You can download the new version here: https://boinc.berkeley.edu/download.php

With best wishes,
Team of SiDock@home
20 Oct 2021, 8:03:32 UTC · Discuss


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What is SiDock@home?

Sidock@home is an international volunteer computing project aimed at drug discovery. The first mission of the project is discovery of possible drugs against the SARS-CoV-2 virus. It started as an extension of the project  COVID.SI to engage the BOINC community into the drug discovery.

You can help with your computer. With the help of BOINC, you will download a subset of compounds on your computer, examine the compounds in the context of the studied target and send the results to a server where they are collected for later analysis.

For account creation please use a Crunch_4Science invitation code. It is not needed when registering by BOINC Manager.

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I am an Aussie born in Canada over seventy years ago, lived in Australia most of my life, including 20+ years in the Australian Defence Force (Army). I...

Donations to SiDock@home

We are going to use donation money for biological evaluation of results.

This project is accepting donations in cryptocurrency:
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  • Bitcoin wallet (BTC): 3GaQD2EBsEAgvdPdpkMGJP3JT5zM3uKNn3
  • Ethereum wallet (ETH): 0xd726c8a048c0532e4793D88895d3cE1A637517c8
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