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Send message Joined: 9 Oct 20 Posts: 185 Credit: 2,782,517 RAC: 142 |
A thread to share news about COVID-19. |
Send message Joined: 30 Oct 20 Posts: 57 Credit: 9,112,528 RAC: 0 |
OK, first the Good News: http://www.dailymagazine.news/aspirin-could-be-key-in-helping-covid-19-patients-recover-nid-1351740.html Now the Bad News: https://www.bbc.com/news/science-environment-54842643 And a bit more Good News: https://www.nytimes.com/2020/11/05/health/coronavirus-ferrets-vaccine-spray.html (may require subscription) https://thehill.com/changing-america/well-being/prevention-cures/524785-nasal-spray-prevents-covid-19-infection-in-test (free version) |
Send message Joined: 3 Nov 20 Posts: 41 Credit: 1,827,356 RAC: 426 |
Some threads where I've posted COVID-19 news links for other projects: Rosetta@home https://boinc.bakerlab.org/rosetta/forum_thread.php?id=13719 World Community Grid https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,42354_offset,0 TN-Grid http://gene.disi.unitn.it/test/forum_thread.php?id=265 Folding@home https://foldingforum.org/viewtopic.php?f=15&t=35927 Expect a lot of duplication between those threads, |
Send message Joined: 30 Oct 20 Posts: 57 Credit: 9,112,528 RAC: 0 |
Common cold antibodies yield clues to COVID-19 behavior Among people who were never infected with the new coronavirus, a few adults - and many children - may have antibodies that can neutralize the virus, researchers reported on Friday in Science. Among 302 such adults, 16 (5.3%) had antibodies, likely generated during infections with "common cold" coronaviruses, that reacted to a specific region of the spike protein on the new virus called the S2 subunit. Among 48 children and adolescents, 21 (43.8%) had these antibodies. In test tube experiments, blood serum from both older and younger uninfected individuals with cross-reactive antibodies could neutralize the new coronavirus. That was not the case with serum from study participants who lacked these antibodies. "Together, these findings may help explain higher COVID-19 susceptibility in older people and provide insight into whether pre-established immunity to seasonal coronaviruses offers protection against SARS-CoV-2," the publishers of the journal said in a statement. The findings also suggest that targeting the S2 subunit on the coronavirus spike protein might be the basis for a drug or vaccine that works on multiple types of coronavirus. (https://bit.ly/3evCSFB)https://news.yahoo.com/common-cold-antibodies-hold-clues-184410434.html |
Send message Joined: 3 Nov 20 Posts: 41 Credit: 1,827,356 RAC: 426 |
English study suggests T cells could be sufficient to protect from COVID-19 https://www.reuters.com/article/us-health-coronavirus-britain-tcell/english-study-suggests-t-cells-could-be-sufficient-to-protect-from-covid-19-idUSKBN27Q004 |
Send message Joined: 28 Oct 20 Posts: 14 Credit: 4,698 RAC: 0 |
English study suggests T cells could be sufficient to protect from COVID-19 Very simliar results from a German study (University of Freiburg): https://www.nature.com/articles/s41591-020-01143-2 |
Send message Joined: 24 Oct 20 Posts: 23 Credit: 9,020 RAC: 0 |
An upcoming paper by the Dreamlab Imperial College of London team will report on their findings. Among them, one caught my eye since we are currently docking molecules against 3CLpro: "For example, among our top-ranked molecules epigallocatechin 3-gallate was demonstrated experimentally to inhibit 3-chymotrypsin-like protease (3CLpro) [38]; I have no idea if that molecule or any of the other 52 phytochemicals they identified as having inhibitory activity on SARS-CoV-2 is being studied here, but I thought I'd share. Congratulations tea (especially green) lovers. Dreamlab is a mobile distributed computing project available for Android and iOS. |
Send message Joined: 19 Dec 20 Posts: 3 Credit: 2,569 RAC: 0 |
Here is an first detailed view of the new UK Covid Mutation that is quickly spreading in UK lately: https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 Just an hour ago the netherlands confirmed the first case of this mutation, named B.1.1.7. It also seems to be more willing to mutate than the "normal" Covid. Conclusion Do you think your able to boot those beasts up soon-ish? |
Send message Joined: 25 Dec 20 Posts: 6 Credit: 28,458 RAC: 0 |
Common cold antibodies yield clues to COVID-19 behavior [...] In case of mutation -- in spike proteins if I remember well -- as we can see in the UK (and spreading a bit everywhere), doesn't it rule this out? One could think the opposite (the mutation weaker to common cold antibodies) but the mutation is for the virus to adapt to its environment, isn't it? Correct me if I'm wrong ; I didn't studied the mutation of viruses in depth (just a bit in biology and biochemistry class at uni before droppint out). micropro |
Send message Joined: 3 Nov 20 Posts: 41 Credit: 1,827,356 RAC: 426 |
The MMR vaccine offers some protection against COVID-19. Analysis of Measles-Mumps-Rubella (MMR) Titers of Recovered COVID-19 Patients https://mbio.asm.org/content/11/6/e02628-20 |
Send message Joined: 3 Nov 20 Posts: 41 Credit: 1,827,356 RAC: 426 |
The Mystery Of India's Plummeting COVID-19 Cases https://www.npr.org/sections/goatsandsoda/2021/02/01/962821038/the-mystery-of-indias-plummeting-covid-19-cases |
Send message Joined: 13 Jan 21 Posts: 76 Credit: 38,846,214 RAC: 0 |
You should model the interaction of these two drug repurposing candidates as SARS therapeutics. How the Search for Covid-19 Treatments Faltered While Vaccines Sped Ahead "Doctors at French psychiatric hospitals had noticed that relatively few patients became ill with Covid-19 compared with the staff members who cared for them. The researchers speculated that the drugs the patients were taking could be protecting them. One of those drugs, the antipsychotic chlorpromazine, had been shown in laboratory experiments to prevent the coronavirus from multiplying." https://www.nytimes.com/2021/01/30/health/covid-drugs-antivirals.html?action=click&module=Spotlight&pgtype=Homepage Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A https://science.sciencemag.org/content/early/2021/01/22/science.abf4058 Could the antipsychotic chlorpromazine be a potential treatment for SARS-CoV-2? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381925/ |
Send message Joined: 3 Nov 20 Posts: 41 Credit: 1,827,356 RAC: 426 |
Licensed drug could reduce SARS-CoV-2 infection by up to 70 per cent, reveals study https://www.eurekalert.org/news-releases/924448 |
Send message Joined: 30 Oct 20 Posts: 57 Credit: 9,112,528 RAC: 0 |
A New Covid Variant On The Loose: B.1.621 A group of seven residents in a Belgian nursing home died after infection with a new variant, all of whom were fully vaccinated according to virologists on the scene. Though the vaccine used in these residents was not made public, it was likely either AstraZeneca or an mRNA vaccine such as Pfizer and Moderna, among those most frequently used in the country.https://www.forbes.com/sites/williamhaseltine/2021/08/12/a-new-killer-on-the-loose-b1621/?sh=6f04c0ea3d1f Looks interesting. |
Send message Joined: 3 Nov 20 Posts: 41 Credit: 1,827,356 RAC: 426 |
Prophylaxis, treatment with probenecid inhibits 'virus replication' in COVID-19, flu, RSV https://www.healio.com/news/rheumatology/20210910/prophylaxis-treatment-with-probenecid-inhibits-virus-replication-in-covid19-flu-rsv?utm_source=selligent&utm_medium=email&utm_campaign=news&M_BT=6620114329042 |
Send message Joined: 3 Nov 20 Posts: 41 Credit: 1,827,356 RAC: 426 |
Lowering Blood Insulin Levels Could Lower Risk Of Getting COVID-19: Study https://medicaldialogues.in/diabetes-endocrinology/news/lowering-blood-insulin-levels-could-lower-risk-of-getting-covid-19-study-83632 |
Send message Joined: 3 Nov 20 Posts: 41 Credit: 1,827,356 RAC: 426 |
Scientists Identify New Antibody For Covid, Variants: Report https://www.ndtv.com/world-news/scientists-identify-new-antibody-for-covid-19-variants-report-2597625 |
Send message Joined: 30 Oct 20 Posts: 57 Credit: 9,112,528 RAC: 0 |
Covid: New heavily mutated variant B.1.1.529 in South Africa raises concern We're back in familiar territory - growing concern about a new variant of coronavirus. The latest is the most heavily mutated version discovered so far - and it has such a long list of mutations that it was described by one scientist as "horrific", while another told me it was the worst variant they'd seen. https://www.bbc.com/news/health-59418127 |
Send message Joined: 30 Oct 20 Posts: 57 Credit: 9,112,528 RAC: 0 |
Two doses of a Covid vaccine are not enough to stop you catching the Omicron variant, UK scientists have warned. https://www.bbc.com/news/health-59615005 |
Send message Joined: 30 Oct 20 Posts: 57 Credit: 9,112,528 RAC: 0 |
Omicron is a wake-up call for COVID-19 vaccine developers Arrival of the highly-mutated Omicron variant is a wake-up call to develop vaccines less susceptible to the rapid changes of the coronavirus, leading virologists and immunologists told Reuters. Most first-generation COVID-19 vaccines target the spike protein on the outer surface of the SARS-CoV-2 virus used to infect human cells. Omicron has prompted alarm among scientists because it has far more mutations than earlier variants, including more than 30 on its spike. Research to determine the extent to which Omicron evades immunity from existing vaccines or prior infection is underway. New data on the Pfizer /BioNTech vaccine show some degree of reduced protection with the two-shot regimen. Even if current shots remain effective for now, the dramatic evolution of the virus highlights the need for vaccines targeting parts of the virus less prone to mutate. "One thing that is clear from Omicron is that the virus... is not going to go away," said Dr. Larry Corey, a virologist at Seattle's Fred Hutchinson Cancer Center who is overseeing U.S. government-backed COVID-19 vaccine trials. "There's a need for better vaccines." https://www.reuters.com/business/healthcare-pharmaceuticals/omicron-is-wake-up-call-covid-19-vaccine-developers-2021-12-08/ |
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